SLFN11 antibody (AA 670-821) (Biotin)

Catalog No. ABIN7168623

Product Details anti-SLFN11 Antibody (Biotin)

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Binding Specificity: AA 670-821

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLFN11 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Schlafen family member 11 protein (670-821AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SLFN11

Target: SLFN11 (Schlafen Family Member 11 (SLFN11))

Alternative Name: SLFN11 (SLFN11 Products)

Synonyms: SLFN8/9 antibody, schlafen family member 11 antibody, SLFN11 antibody, LOC100071612 antibody

Background:

Background: Interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis. Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner. Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides. The exact inhibition mechanism is unclear: may either sequesters tRNAs, prevents their maturation via post-transcriptional processing or accelerates their deacylation. Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA. May play a role in cell cycle arrest and/or induction of apoptosis in response to exogenously induced DNA damage.

Aliases: SLFN11 antibody, Schlafen family member 11 antibody, EC 3.6.-.- antibody

UniProt: Q7Z7L1