RYR2 antibody (AA 901-1192)

Catalog No. ABIN7168509

Product Details anti-RYR2 Antibody

Target: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Binding Specificity: AA 901-1192

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RYR2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ryanodine receptor 2 protein (901-1192AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RYR2

Target: RYR2 (Ryanodine Receptor 2 (Cardiac) (RYR2))

Alternative Name: RYR2 (RYR2 Products)

Synonyms: RYR2 antibody, ARVC2 antibody, ARVD2 antibody, RYR-2 antibody, RyR antibody, VTSIP antibody, 9330127I20Rik antibody, ryanodine receptor 2 antibody, ryanodine receptor 2, cardiac antibody, RYR2 antibody, Ryr2 antibody

Background:

Background: Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Aliases: ARVC2 antibody, ARVD2 antibody, Cardiac muscle ryanodine receptor antibody, Cardiac muscle ryanodine receptor-calcium release channel antibody, hRYR-2 antibody, ryanodine receptor 2 (cardiac) antibody, Ryanodine receptor 2 antibody, RyR antibody, RYR-2 antibody, RyR2 antibody, RYR2_HUMAN antibody, Type 2 ryanodine receptor antibody, VTSIP antibody

UniProt: Q92736

Pathways: Myometrial Relaxation and Contraction