RC3H2 antibody (AA 251-506) (Biotin)
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- Target See all RC3H2 products
- RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))
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Binding Specificity
- AA 251-506
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This RC3H2 antibody is conjugated to Biotin
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Application
- ELISA
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Roquin-2 protein (251-506AA)
- Isotype
- IgG
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- RC3H2 (Membrane Associated DNA Binding Protein (RC3H2))
- Alternative Name
- RC3H2 (RC3H2 Products)
- Synonyms
- Mnab antibody, MNAB antibody, RNF164 antibody, 2900024N03Rik antibody, 9430019J22Rik antibody, D930043C02Rik antibody, Rnf164 antibody, ring finger and CCCH-type domains 2 antibody, ring finger and CCCH-type zinc finger domains 2 antibody, Rc3h2 antibody, RC3H2 antibody
- Background
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Background: Post-transcriptional repressor of mRNAs containing a conserved stem loop motif, called constitutive decay element (CDE), which is often located in the 3\'-UTR, as in HMGXB3, ICOS, IER3, NFKBID, NFKBIZ, PPP1R10, TNF and in many more mRNAs. Binds to CDE and promotes mRNA deadenylation and degradation. This process does not involve miRNAs. In follicular helper T (Tfh) cells, represses of ICOS and TNFRSF4 expression, thus preventing spontaneous Tfh cell differentiation, germinal center B-cell differentiation in the absence of immunization and autoimmunity. In resting or LPS-stimulated macrophages, controls inflammation by suppressing TNF expression. Also recognizes CDE in its own mRNA and in that of paralogous RC3H2, possibly leading to feedback loop regulation. May act as a ubiquitin E3 ligase. Involved in the ubiquitination of MAP3K5 (PubMed:24448648).
Aliases: 2900024N03Rik antibody, 9430019J22Rik antibody, D930043C02Rik antibody, FLJ20301 antibody, FLJ20713 antibody, Membrane associated DNA binding protein antibody, Membrane associated nucleic acid binding protein antibody, Membrane-associated nucleic acid-binding protein antibody, MGC52176 antibody, MNAB antibody, OTTHUMP00000022076 antibody, OTTHUMP00000022077 antibody, OTTMUSP00000013545 antibody, OTTMUSP00000013546 antibody, Rc3h2 antibody, RC3H2_HUMAN antibody, Ring finger and CCCH type domains 2 antibody, RING finger and CCCH type zinc finger domain containing protein 2 antibody, Ring finger and CCCH-type zinc finger domain-containing protein 2 antibody, ring finger and CCCH-type zinc finger domains 2 antibody, RING finger protein 164 antibody, RNF164 antibody, roquin-2 antibody, RP23-321B3.1 antibody
- UniProt
- Q9HBD1
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