RRM2B antibody (AA 1-351)

Catalog No. ABIN7168147

Product Details anti-RRM2B Antibody

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Binding Specificity: AA 1-351

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRM2B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 B protein (1-351AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RRM2B

Target: RRM2B (Ribonucleotide Reductase M2 B (TP53 Inducible) (RRM2B))

Alternative Name: RRM2B (RRM2B Products)

Synonyms: p53r2 antibody, RRM2B antibody, MTDPS8A antibody, MTDPS8B antibody, P53R2 antibody, p53R2 antibody, ribonucleotide reductase M2 B (TP53 inducible) S homeolog antibody, ribonucleotide reductase regulatory TP53 inducible subunit M2B antibody, ribonucleotide reductase M2 B (TP53 inducible) antibody, rrm2b.S antibody, RRM2B antibody, rrm2b antibody, Rrm2b antibody

Background:

Background: Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage.

Aliases: DKFZp686M05248 antibody, MGC102856 antibody, MGC42116 antibody, MTDPS8A antibody, MTDPS8B antibody, p53 inducible ribonucleotide reductase small subunit 2 homolog antibody, p53 inducible ribonucleotide reductase small subunit 2 like protein antibody, P53 inducible ribonucleotide reductase small subunit 2 short form beta antibody, p53 R2 antibody, p53-inducible ribonucleotide reductase small subunit 2-like protein antibody, p53R2 antibody, Ribonucleoside diphosphate reductase M2 subunit B antibody, Ribonucleoside-diphosphate reductase subunit M2 B antibody, Ribonucleotide reductase M2 B (TP53 inducible) antibody, Ribonucleotide reductase M2 B antibody, Ribonucleotide reductase small subunit like 2 p53 inducible antibody, RIR2B_HUMAN antibody, RRM 2B antibody, RRM2B antibody, TP53 inducible ribonucleotide reductase M2 B antibody, TP53-inducible ribonucleotide reductase M2 B antibody

UniProt: Q7LG56

Pathways: p53 Signaling, Negative Regulation of intrinsic apoptotic Signaling