RAB23 antibody (AA 18-234) (Biotin)

Catalog No. ABIN7167255

Product Details anti-RAB23 Antibody (Biotin)

Target: RAB23 (RAB23, Member RAS Oncogene Family (RAB23))

Binding Specificity: AA 18-234

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RAB23 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ras-related protein Rab-23 protein (18-234aa)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RAB23

Target: RAB23 (RAB23, Member RAS Oncogene Family (RAB23))

Alternative Name: RAB23 (RAB23 Products)

Synonyms: MGC82152 antibody, hspc137 antibody, zgc:110261 antibody, AW545388 antibody, opb antibody, opb2 antibody, HSPC137 antibody, Rab23-like antibody, RAB23, member RAS oncogene family S homeolog antibody, RAB23, member RAS oncogene family antibody, ras-related protein Rab-23 antibody, rab23.S antibody, RAB23 antibody, rab23 antibody, Rab23 antibody

Background:

Background: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Together with SUFU, prevents nuclear import of GLI1, and thereby inhibits GLI1 transcription factor activity. Regulates GLI1 in differentiating chondrocytes. Likewise, regulates GLI3 proteolytic processing and modulates GLI2 and GLI3 transcription factor activity. Plays a role in autophagic vacuole assembly, and mediates defense against pathogens, such as S.aureus, by promoting their capture by autophagosomes that then merge with lysosomes.

Aliases: Ras-related protein Rab-23, RAB23

UniProt: Q9ULC3

Pathways: Tube Formation