RRAGA antibody (AA 1-247) (HRP)

Catalog No. ABIN7167208

Product Details anti-RRAGA Antibody (HRP)

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Binding Specificity: AA 1-247

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RRAGA antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Ras-related GTP-binding protein A protein (1-247AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RRAGA

Target: RRAGA (Ras-Related GTP Binding A (RRAGA))

Alternative Name: RRAGA (RRAGA Products)

Synonyms: FIP-1 antibody, FIP1 antibody, RAGA antibody, 1300010C19Rik antibody, AI255374 antibody, Raga antibody, Ras related GTP binding A antibody, Ras-related GTP binding A antibody, RRAGA antibody, Rraga antibody

Background:

Background: Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade. Forms heterodimeric Rag complexes with RRAGC or RRAGD and cycles between an inactive GDP-bound and an active GTP-bound form. In its active form participates in the relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14.7K, an inhibitor of TNF-alpha functions, thereby affecting cell death.

Aliases: Adenovirus E3 14.7 kDa-interacting protein 1 antibody, FIP-1 antibody, Rag A antibody, RagA antibody, Ras-related GTP-binding protein A antibody, RRAGA antibody, RRAGA_HUMAN antibody

UniProt: Q7L523