MAPKSP1 antibody (AA 1-124)

Catalog No. ABIN7167072

Product Details anti-MAPKSP1 Antibody

Target: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Binding Specificity: AA 1-124

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPKSP1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Ragulator complex protein LAMTOR3 protein (1-124AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAPKSP1

Target: MAPKSP1 (Mitogen-Activated Protein Kinase Kinase 1 Interacting Protein 1 (MAPKSP1))

Alternative Name: LAMTOR3 (MAPKSP1 Products)

Synonyms: MAPKSP1 antibody, MAP2K1IP1 antibody, MAPBP antibody, MP1 antibody, PRO0633 antibody, Ragulator3 antibody, AW556229 antibody, Map2k1ip1 antibody, Mapbp antibody, Mapksp1 antibody, Mp1 antibody, mapksp1 antibody, zgc:110207 antibody, late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 antibody, LAMTOR3 antibody, Lamtor3 antibody, lamtor3 antibody

Background:

Background: As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Aliases: LAMTOR3 antibody, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 3 antibody, LTOR3_HUMAN antibody, MAP2K1IP1 antibody, MEK binding partner 1 antibody, MEK partner 1 antibody, MEK-binding partner 1 antibody, Mitogen activated protein kinase kinase 1 interacting protein 1 antibody, Mitogen-activated protein kinase kinase 1-interacting protein 1 antibody, Mitogen-activated protein kinase scaffold protein 1 antibody, Mp1 antibody, Ragulator complex protein LAMTOR3 antibody

UniProt: Q9UHA4

Pathways: PI3K-Akt Signaling