R-Spondin 3 antibody (AA 22-272)

Catalog No. ABIN7166936

Product Details anti-R-Spondin 3 Antibody

Target: R-Spondin 3 (RSPO3)

Binding Specificity: AA 22-272

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This R-Spondin 3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human R-spondin-3 protein (22-272AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for R-Spondin 3

Target: R-Spondin 3 (RSPO3)

Alternative Name: RSPO3 (RSPO3 Products)

Synonyms: pwtsr antibody, thsd2 antibody, cristin1 antibody, CRISTIN1 antibody, PWTSR antibody, THSD2 antibody, RGD1563246 antibody, 2810459H04Rik antibody, AW742308 antibody, Cristin1 antibody, Thsd2 antibody, R-spondin 3 antibody, rspo3 antibody, RSPO3 antibody, Rspo3 antibody

Background:

Background: Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors. Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway.

Aliases: CRISTIN1 antibody, hPWTSR antibody, hRspo3 antibody, Protein with TSP type-1 repeat antibody, PWTSR antibody, R-spondin 3 homolog antibody, R-spondin-3 [Precursor] antibody, R-spondin-3 antibody, Roof plate specific spondin-3 antibody, Roof plate-specific spondin-3 antibody, RSPO3 antibody, RSPO3_HUMAN antibody, Thrombospondin type I domain containing 2 antibody, Thrombospondin type-1 domain-containing protein 2 antibody, THSD2 antibody

UniProt: Q9BXY4