PYHIN1 antibody (AA 1-245)

Catalog No. ABIN7166880

Product Details anti-PYHIN1 Antibody

Target: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Binding Specificity: AA 1-245

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PYHIN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Pyrin and HIN domain-containing protein 1 protein (1-245AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PYHIN1

Target: PYHIN1 (Pyrin and HIN Domain Family, Member 1 (PYHIN1))

Alternative Name: PYHIN1 (PYHIN1 Products)

Synonyms: IFIX antibody, RP11-520H16.1 antibody, 4930422C14 antibody, AI447904 antibody, Ifi209 antibody, Ifix antibody, pyrin and HIN domain family member 1 antibody, interferon activated gene 209 antibody, PYHIN1 antibody, Ifi209 antibody

Background:

Background: Major mediator of the tumor suppressor activity of IFN in breast cancer cells. Promotes ubiquitination and subsequent degradation of MDM2, which leads to p53/TP53 stabilization. Promotes ubiquitination and subsequent degradation of HDAC1, which in turn enhances maspin expression, and impairs invasive activity of cancer cells.

Aliases: IFIX_HUMAN antibody, Interferon-inducible protein X antibody, Pyhin1 antibody, Pyrin and HIN domain-containing protein 1 antibody

UniProt: Q6K0P9