SBNO2 antibody (AA 6-146) (Biotin)

Catalog No. ABIN7166167

Product Details anti-SBNO2 Antibody (Biotin)

Target: SBNO2 (Strawberry Notch Homolog 2 (SBNO2))

Binding Specificity: AA 6-146

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SBNO2 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Protein strawberry notch homolog 2 protein (6-146AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SBNO2

Target: SBNO2 (Strawberry Notch Homolog 2 (SBNO2))

Alternative Name: SBNO2 (SBNO2 Products)

Synonyms: KIAA0963 antibody, SNO antibody, STNO antibody, BC019206 antibody, F730040C21 antibody, Sno antibody, Stno antibody, strawberry notch homolog 2 antibody, strawberry notch homolog 2 (Drosophila) antibody, SBNO2 antibody, Sbno2 antibody

Background:

Background: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis, required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages (PubMed:18025162). Plays a role as a regulator in the proinflammatory cascade (PubMed:18025162).

Aliases: SBNO2 antibody, KIAA0963Protein strawberry notch homolog 2 antibody

UniProt: Q9Y2G9