Patched 1 antibody (AA 1180-1411)

Catalog No. ABIN7165903

Product Details anti-Patched 1 Antibody

Target: Patched 1 (PTCH1)

Binding Specificity: AA 1180-1411

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Patched 1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Protein patched homolog 1 protein (1180-1411AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Patched 1

Target: Patched 1 (PTCH1)

Alternative Name: PTCH1 (PTCH1 Products)

Synonyms: BCNS antibody, HPE7 antibody, NBCCS antibody, PTC antibody, PTC1 antibody, PTCH antibody, PTCH11 antibody, lep antibody, ptc1 antibody, ptc2 antibody, Ptch antibody, Ptch2 antibody, Ptc-1 antibody, XPtc1 antibody, patched antibody, patched1 antibody, A230106A15Rik antibody, Ptc antibody, Ptc1 antibody, mes antibody, patched 1 antibody, patched 1 L homeolog antibody, Protein patched homolog 1 antibody, PTCH1 antibody, ptch1 antibody, Ptch1 antibody, ptch1.L antibody, ptc-1 antibody

Background:

Background: Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog\'s proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.

Aliases: A230106A15Rik antibody, BCNS antibody, FLJ26746 antibody, FLJ42602 antibody, Holoprosencephaly 7 antibody, HPE7 antibody, mes antibody, NBCCS antibody, OTTHUMP00000021709 antibody, OTTHUMP00000021710 antibody, Patched antibody, Patched (Drosophila) homolog antibody, Patched 1 antibody, Patched homolog (Drosophila) antibody, Patched homolog 1 (Drosophila) antibody, Patched homolog 1 antibody, Patched protein homolog 1 antibody, Protein patched homolog 1 antibody, PTC antibody, PTC1 antibody, PTC1_HUMAN antibody, PTCH antibody, PTCH protein +12b antibody, PTCH protein +4' antibody, PTCH protein -10 antibody, PTCH protein antibody, ptch1 antibody, PTCH1 protein antibody, PTCH11 antibody, Ptch2 antibody

UniProt: Q13635

Pathways: Hedgehog Signaling, Carbohydrate Homeostasis, Tube Formation