MAGOH antibody (AA 1-146)

Catalog No. ABIN7165791

Product Details anti-MAGOH Antibody

Target: MAGOH (Mago-Nashi Homolog (MAGOH))

Binding Specificity: AA 1-146

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAGOH antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Protein mago nashi homolog protein (1-146AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAGOH

Target: MAGOH (Mago-Nashi Homolog (MAGOH))

Alternative Name: MAGOH (MAGOH Products)

Synonyms: MAGOH1 antibody, MAGOHA antibody, Mago-m antibody, Mos2 antibody, MAGOH antibody, zgc:112220 antibody, mago antibody, xl-mago antibody, CG9401 antibody, Dm MGN antibody, DmMago antibody, Dmel\CG9401 antibody, MGN antibody, Mago antibody, Magoh antibody, l(2)57Ca antibody, mgn antibody, magoh antibody, mago homolog, exon junction complex core component antibody, protein mago nashi homolog antibody, mago homolog, exon junction complex core component L homeolog antibody, mago nashi antibody, MAGOH antibody, Magoh antibody, LOC736868 antibody, magoh antibody, magoh.L antibody, mago antibody, LOC106584057 antibody

Background:

Background: Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). The MAGOH-RBM8A heterodimer inhibits the ATPase activity of EIF4A3, thereby trapping the ATP-bound EJC core onto spliced mRNA in a stable conformation. The MAGOH-RBM8A heterodimer interacts with the EJC key regulator PYM1 leading to EJC disassembly in the cytoplasm and translation enhancement of EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S preinitiation complex. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes), specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S), the function is different from the established EJC assembly.

Aliases: Mago nashi homolog proliferation associated (Drosophila) antibody, Mago nashi protein homolog antibody, magoh antibody, MAGOHA antibody, MGN_HUMAN antibody, Protein mago nashi homolog antibody

UniProt: P61326