HOOK3 antibody (AA 357-455)

Catalog No. ABIN7165641

Product Details anti-HOOK3 Antibody

Target: HOOK3 (Hook Homolog 3 (HOOK3))

Binding Specificity: AA 357-455

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HOOK3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Protein Hook homolog 3 protein (357-455AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:200-1:500, IP:1:200-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HOOK3

Target: HOOK3 (Hook Homolog 3 (HOOK3))

Alternative Name: HOOK3 (HOOK3 Products)

Synonyms: 5830454D03Rik antibody, AI317159 antibody, E330005F07Rik antibody, HK3 antibody, hook3 antibody, hook microtubule-tethering protein 3 antibody, hook microtubule tethering protein 3 antibody, hook microtubule-tethering protein 3 L homeolog antibody, Hook3 antibody, HOOK3 antibody, hook3.L antibody

Background:

Background: Probably serves as a target for the spiC protein from Salmonella typhimurium, which inactivates it, leading to a strong alteration in cellular trafficking (By similarity). Component of the FTS/Hook/FHIP complex (FHF complex). The FHF complex may function to promote vesicle trafficking and/or fusion via the homotypic vesicular protein sorting complex (the HOPS complex). May regulate clearance of endocytosed receptors such as MSR1. Participates in defining the architecture and localization of the Golgi complex. Acts as an adapter protein linking the dynein motor complex to various cargos and converts dynein from a non-processive to a highly processive motor in the presence of dynactin. Facilitates the interaction between dynein and dynactin and activates dynein processivity (the ability to move along a microtubule for a long distance without falling off the track) (PubMed:25035494).

Aliases: FLJ31058 antibody, h-hook3 antibody, hHK3 antibody, HK3 antibody, hook3 antibody, HOOK3_HUMAN antibody, OTTHUMP00000229200 antibody, Protein Hook homolog 3 antibody

UniProt: Q86VS8

Pathways: Stem Cell Maintenance, Maintenance of Protein Location