PSMA7 antibody (AA 5-232)

Catalog No. ABIN7164964

Product Details anti-PSMA7 Antibody

Target: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Binding Specificity: AA 5-232

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSMA7 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Proteasome subunit alpha type-7 protein (5-232AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSMA7

Target: PSMA7 (Proteasome Subunit alpha 7 (PSMA7))

Alternative Name: PSMA7 (PSMA7 Products)

Synonyms: C6 antibody, HSPC antibody, RC6-1 antibody, XAPC7 antibody, C6-I antibody, DDBDRAFT_0185059 antibody, DDBDRAFT_0217080 antibody, DDB_0185059 antibody, DDB_0217080 antibody, hspc antibody, rc6-1 antibody, xapc7 antibody, psma7 antibody, psma4-B antibody, proteasome subunit alpha 7 antibody, proteasome (prosome, macropain) subunit, alpha type 7 antibody, 20S proteasome subunit alpha-7 antibody, proteasome subunit alpha 7 S homeolog antibody, proteasome subunit alpha 7 L homeolog antibody, PSMA7 antibody, Psma7 antibody, psmA7 antibody, psma7 antibody, psma7.S antibody, psma7.L antibody

Background:

Background: The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH . The proteasome has an ATP-dependent proteolytic activity. Plays an important role in the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. Interacts with some important proteins involved in transcription factor regulation, cell cycle transition, viral replication and even tumor initiation and progression. Inhibits the transactivation function of HIF-1A under both normoxic and hypoxia-mimicking conditions. The interaction with EMAP2 increases the proteasome-mediated HIF-1A degradation under the hypoxic conditions. Plays a role in hepatitis C virus internal ribosome entry site-mediated translation. Mediates nuclear translocation of the androgen receptor (AR) and thereby enhances androgen-mediated transactivation. Promotes MAVS degradation and thereby negatively regulates MAVS-mediated innate immune response

Aliases: C6 antibody, HSPC antibody, MGC3755 antibody, OTTHUMP00000031449 antibody, OTTHUMP00000031450 antibody, OTTHUMP00000031453 antibody, Proteasome (prosome macropain) subunit alpha type 7 antibody, Proteasome alpha 7 subunit antibody, Proteasome subunit alpha 4 antibody, Proteasome subunit alpha type 7 antibody, Proteasome subunit alpha type-7 antibody, Proteasome subunit RC6 1 antibody, Proteasome subunit RC6-1 antibody, Proteasome subunit XAPC7 antibody, PSA7_HUMAN antibody, PSMA 7 antibody, PSMA7 antibody, RC6 1 antibody, XAPC7 antibody

UniProt: O14818

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Synthesis of DNA