PSME4 antibody (AA 105-198)

Catalog No. ABIN7164923

Product Details anti-PSME4 Antibody

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Binding Specificity: AA 105-198

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSME4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Proteasome activator complex subunit 4 protein (105-198AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:500-1:1000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSME4

Target: PSME4 (Proteasome (Prosome, Macropain) Activator Subunit 4 (PSME4))

Alternative Name: PSME4 (PSME4 Products)

Synonyms: proteasome activating protein 200 antibody, Afu4g11290 antibody, An04g05320 antibody, AO090003001091 antibody, PA200 antibody, AA409398 antibody, AU041366 antibody, TEMO antibody, mKIAA0077 antibody, proteasome activator subunit 4 antibody, proteasome activating protein 200 antibody, proteasome (prosome, macropain) activator subunit 4 antibody, PSME4 antibody, Psme4 antibody, PA200 antibody, AFUA_4G11290 antibody, ANI_1_888184 antibody, AOR_1_1944154 antibody, TERG_07227 antibody, psme4 antibody

Background:

Background: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.

Aliases: KIAA0077 antibody, PA200 antibody, Proteasome Activator 200 kDa antibody, Proteasome activator complex subunit 4 antibody, Proteasome activator PA200 antibody, PSME 4 antibody, psme4 antibody, PSME4_HUMAN antibody

UniProt: Q14997

Pathways: DNA Replication, Synthesis of DNA