PSME3 antibody (AA 2-252)

Catalog No. ABIN7164919

Product Details anti-PSME3 Antibody

Target: PSME3

Binding Specificity: AA 2-252

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PSME3 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Proteasome activator complex subunit 3 protein (2-252AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PSME3

Target: PSME3

Alternative Name: PSME3 (PSME3 Products)

Synonyms: AA410043 antibody, AU020960 antibody, Ki antibody, PA28gamma antibody, REGgamma antibody, pa28g antibody, Ab2-371 antibody, PA28-gamma antibody, PA28G antibody, REG-GAMMA antibody, psme3b antibody, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antibody, proteasome activator subunit 3 antibody, proteasome activator subunit 3 S homeolog antibody, Psme3 antibody, PSME3 antibody, psme3.S antibody

Background:

Background: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.

Aliases: 11S regulator complex gamma subunit antibody, 11S regulator complex subunit gamma antibody, Activator of multicatalytic protease subunit 3 antibody, Ki antibody, Ki antigen antibody, Ki nuclear autoantigen antibody, Ki, PA28 gamma antibody, PA28 gamma antibody, PA28g antibody, PA28gamma antibody, Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antibody, Proteasome (prosome, macropain) activator subunit 3 antibody, Proteasome activator 28 gamma antibody, Proteasome activator 28 subunit gamma antibody, Proteasome activator complex subunit 3 antibody, Proteasome activator subunit 3 antibody, PSME3 antibody, PSME3_HUMAN antibody, REG GAMMA antibody, REG-gamma antibody

UniProt: P61289

Pathways: Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA