HBEGF antibody (AA 63-148)

Catalog No. ABIN7164700

Product Details anti-HBEGF Antibody

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Binding Specificity: AA 63-148

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HBEGF antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Proheparin-binding EGF-like growth factor protein (63-148AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for HBEGF

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Alternative Name: HBEGF (HBEGF Products)

Synonyms: hbegf antibody, zgc:165443 antibody, HBEGF antibody, zgc:175091 antibody, DTR antibody, DTS antibody, DTSF antibody, HEGFL antibody, Dtr antibody, GFHB antibody, Hb-egf antibody, Hegfl antibody, AW047313 antibody, Dts antibody, HB-EGF antibody, heparin-binding EGF-like growth factor b antibody, heparin binding EGF like growth factor antibody, Heparin-binding EGF-like growth factor antibody, heparin-binding EGF-like growth factor a antibody, heparin-binding EGF-like growth factor antibody, hbegfb antibody, HBEGF antibody, hbegf antibody, hbegfa antibody, Hbegf antibody

Background:

Background: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Aliases: diphtheria toxin receptor (heparin-binding EGF-like growth factor) antibody, diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor) antibody, Diphtheria toxin receptor antibody, DT R antibody, DT-R antibody, DTR antibody, DTS antibody, DTSF antibody, HB-EGF antibody, HBEGF antibody, HBEGF_HUMAN antibody, HEGFL antibody, Heparin binding EGF like growth factor antibody, Heparin binding epidermal growth factor antibody, Heparin binding epidermal growth factor like growth factor antibody, Heparin-binding EGF-like growth factor antibody, Proheparin binding EGF like growth factor antibody

UniProt: Q99075

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway