Lamin A/C antibody (AA 385-572)

Catalog No. ABIN7164247

Product Details anti-Lamin A/C Antibody

Target: Lamin A/C (LMNA)

Binding Specificity: AA 385-572

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Lamin A/C antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Rat

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Prelamin-A/C protein (385-572AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:200-1:500, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Lamin A/C

Target: Lamin A/C (LMNA)

Alternative Name: LMNA (LMNA Products)

Background:

Background: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation. Required for osteoblastogenesis and bone formation. Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone.

Aliases: 70 kDa lamin antibody, Cardiomyopathy dilated 1A (autosomal dominant) antibody, CDCD1 antibody, CDDC antibody, CMD1A antibody, CMT2B1 antibody, EMD2 antibody, FPL antibody, FPLD antibody, FPLD2 antibody, HGPS antibody, IDC antibody, Lamin A antibody, Lamin A/C antibody, Lamin A/C like 1 antibody, Lamin antibody, Lamin C antibody, lamin-a antibody, Lamin-A/C antibody, LDP1 antibody, LFP antibody, LGMD1B antibody, Limb girdle muscular dystrophy 1B (autosomal dominant) antibody, LMN 1 antibody, LMN A antibody, LMN C antibody, LMN1 antibody, LMNA antibody, LMNA_HUMAN antibody, LMNC antibody, LMNL1 antibody, Prelamin A/C antibody, PRO1 antibody, Renal carcinoma antigen NY REN 32 antibody, Renal carcinoma antigen NY-REN-32 antibody, Renal carcinoma antigen NYREN32 antibody

UniProt: P02545

Pathways: Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus