PQBP1 antibody (AA 2-265) (HRP)

Catalog No. ABIN7163843

Product Details anti-PQBP1 Antibody (HRP)

Target: PQBP1 (Polyglutamine Binding Protein 1 (PQBP1))

Binding Specificity: AA 2-265

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PQBP1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Polyglutamine-binding protein 1 protein (2-265AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PQBP1

Target: PQBP1 (Polyglutamine Binding Protein 1 (PQBP1))

Alternative Name: PQBP1 (PQBP1 Products)

Synonyms: PQBP1 antibody, MRX55 antibody, MRXS3 antibody, MRXS8 antibody, NPW38 antibody, RENS1 antibody, SHS antibody, PQBP-1 antibody, Sfc2 antibody, npw38 antibody, polyglutamine binding protein 1 antibody, PQBP1 antibody, Pqbp1 antibody

Background:

Background: Probably functions as scaffold protein that is part of numerous complexes and thereby plays a role in pre-mRNA splicing, transcription regulation and neuron development. Required for normal alternative splicing of target pre-mRNA species (PubMed:23512658). May suppress the ability of POU3F2 to transactivate the DRD1 gene in a POU3F2 dependent manner. Can activate transcription directly or via association with the transcription machinery. May be involved in ATXN1 mutant-induced cell death. The interaction with ATXN1 mutant reduces levels of phosphorylated RNA polymerase II large subunit.

Aliases: 38 kDa nuclear protein containing a WW domain antibody, Mental retardation, X linked 55 antibody, MRX55 antibody, MRXS3 antibody, MRXS8 antibody, Npw38 antibody, Nuclear protein containing WW domain 38 kD antibody, OTTHUMP00000025808 antibody, Polyglutamine binding protein 1 antibody, Polyglutamine tract binding protein 1 antibody, Polyglutamine tract-binding protein 1 antibody, Polyglutamine-binding protein 1 antibody, PQBP 1 antibody, PQBP-1 antibody, PQBP1 antibody, PQBP1_HUMAN antibody, RENS1 antibody, SHS antibody, Sutherland Haan X linked mental retardation syndrome antibody

UniProt: O60828

Pathways: Ribonucleoprotein Complex Subunit Organization