PARP3 antibody (AA 294-533)

Catalog No. ABIN7163755

Product Details anti-PARP3 Antibody

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Binding Specificity: AA 294-533

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Western Blotting (WB), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Poly [ADP-ribose] polymerase 3 protein (294-533AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PARP3

Target: PARP3 (Poly (ADP-Ribose) Polymerase Family, Member 3 (PARP3))

Alternative Name: PARP3 (PARP3 Products)

Synonyms: ADPRT-3 antibody, PARP-3 antibody, PM38 antibody, Adprtl3 antibody, fj17c06 antibody, wu:fj17c06 antibody, zgc:66157 antibody, PARP3 antibody, parp3 antibody, ADPRT3 antibody, ADPRTL2 antibody, ADPRTL3 antibody, ARTD3 antibody, IRT1 antibody, PADPRT-3 antibody, A930002C11Rik antibody, AW990611 antibody, Adprt3 antibody, pADPRT-3 antibody, seed maturation protein PM38 antibody, poly (ADP-ribose) polymerase family, member 3 antibody, poly(ADP-ribose) polymerase family member 3 antibody, poly(ADP-ribose) polymerase family member 3 L homeolog antibody, PARP3 antibody, parp3 antibody, parp3.L antibody, Parp3 antibody

Background:

Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.

Aliases: ADP ribosyltransferase (NAD+, poly (ADP ribose) antibody, ADP ribosyltransferase diphtheria toxin like 3 antibody, ADPRT-3 antibody, ADPRT3 antibody, ADPRTL2 antibody, ADPRTL3 antibody, ARTD3 antibody, hPARP 3 antibody, hPARP-3 antibody, hPARP3 antibody, IRT 1 antibody, IRT1 antibody, NAD(+) ADP ribosyltransferase 3 antibody, NAD(+) ADP-ribosyltransferase 3 antibody, NAD+ ADP ribosyltransferase 3 antibody, pADPRT 3 antibody, pADPRT-3 antibody, pADPRT3 antibody, PARP 3 antibody, PARP-3 antibody, PARP3 antibody, PARP3_HUMAN antibody, Poly (ADP ribose) polymerase family, member 3 antibody, Poly (ADP ribose) synthetase 3 antibody, Poly [ADP-ribose] polymerase 3 antibody, Poly[ADP ribose] synthetase 3 antibody, Poly[ADP-ribose] synthase 3 antibody

UniProt: Q9Y6F1