PARP2 antibody (AA 14-149) (Biotin)

Catalog No. ABIN7163748

Product Details anti-PARP2 Antibody (Biotin)

Target: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Binding Specificity: AA 14-149

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PARP2 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Poly [ADP-ribose] polymerase 2 protein (14-149AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PARP2

Target: PARP2 (Poly (ADP-Ribose) Polymerase 2 (PARP2))

Alternative Name: PARP2 (PARP2 Products)

Synonyms: ADPRT2 antibody, ADPRTL2 antibody, ADPRTL3 antibody, ARTD2 antibody, PARP-2 antibody, pADPRT-2 antibody, Adprt2 antibody, Adprtl2 antibody, Aspartl2 antibody, C78626 antibody, cb996 antibody, adprtl2 antibody, ADPRT-2 antibody, APP antibody, ATPARP1 antibody, PARP1 antibody, POLY(ADP-RIBOSE) POLYMERASE antibody, POLY(ADP-RIBOSE) POLYMERASE 1 antibody, PP antibody, T14P8.19 antibody, T14P8_19 antibody, poly(ADP-ribose) polymerase antibody, poly(ADP-ribose) polymerase 2 antibody, poly(ADP-ribose) polymerase 2 antibody, poly (ADP-ribose) polymerase family, member 2 antibody, poly (ADP-ribose) polymerase 2 antibody, poly(ADP-ribose) polymerase 2 S homeolog antibody, poly(ADP-ribose) polymerase antibody, PARP2 antibody, Parp2 antibody, parp2 antibody, parp2.S antibody

Background:

Background: Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231). Mediates serine ADP-ribosylation of target proteins following interaction with HPF1, HPF1 conferring serine specificity (PubMed:28190768).

Aliases: ADP ribosyltransferase like 2 antibody, ADP-ribosyltransferase diphtheria toxin-like 2 antibody, ADPRT 2 antibody, ADPRT-2 antibody, ADPRT2 antibody, ADPRTL 2 antibody, ADPRTL 3 antibody, ADPRTL2 antibody, ADPRTL3 antibody, ARTD2 antibody, hPARP 2 antibody, hPARP-2 antibody, hPARP2 antibody, NAD(+) ADP ribosyltransferase 2 antibody, NAD(+) ADP-ribosyltransferase 2 antibody, pADPRT 2 antibody, pADPRT-2 antibody, pADPRT2 antibody, PARP 2 antibody, PARP-2 antibody, PARP2 antibody, PARP2_HUMAN antibody, Poly (ADP ribose) polymerase family member 2 antibody, Poly (ADP ribosyl) transferase like 2 antibody, poly (ADP-ribose) polymerase 2 antibody, Poly [ADP ribose] synthetase 2 antibody, Poly [ADP-ribose] polymerase 2 antibody, Poly(ADP ribose) synthetase antibody, Poly[ADP-ribose] synthase 2 antibody

UniProt: Q9UGN5

Pathways: DNA Damage Repair