Pleiotrophin antibody (AA 33-168)

Catalog No. ABIN7163691

Product Details anti-Pleiotrophin Antibody

Target: Pleiotrophin (PTN)

Binding Specificity: AA 33-168

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Pleiotrophin antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Pleiotrophin protein (33-168AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Pleiotrophin

Target: Pleiotrophin (PTN)

Alternative Name: PTN (PTN Products)

Synonyms: zHBNF antibody, zgc:111787 antibody, harp antibody, hbnf antibody, X-PTF antibody, hbgf8 antibody, negf1 antibody, ptn antibody, PTN antibody, HARP antibody, HBGF8 antibody, HBNF antibody, NEGF1 antibody, PTN-A antibody, HB-GAM antibody, HBBM antibody, HBGF-8 antibody, OSF-1 antibody, HBBN antibody, OSF antibody, Osf-1 antibody, Osf1 antibody, Hbnf antibody, pleiotrophin antibody, pleiotrophin L homeolog antibody, ptn antibody, PTN antibody, ptn.L antibody, Ptn antibody

Background:

Background: Secreted growth factor that induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells (PubMed:1768439, PubMed:1733956). Binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation (PubMed:11278720). Binds to cell-surface target proteins via their chondroitin sulfate groups (PubMed:26896299). Down-regulates PTPRZ1 activity (PubMed:16814777).

Aliases: HARP antibody, HB-GAM antibody, HBBM antibody, HBGAM antibody, HBGF-8 antibody, HBGF8 antibody, HBNF antibody, HBNF-1 antibody, HBNF1 antibody, heparin affin regulatory protein antibody, Heparin binding growth associated molecule antibody, Heparin binding growth factor 8 antibody, Heparin binding neurite outgrowth promoting factor 1 antibody, Heparin-binding brain mitogen antibody, Heparin-binding growth factor 8 antibody, Heparin-binding growth-associated molecule antibody, heparin-binding neurite outgrowth promoting factor antibody, Heparin-binding neurite outgrowth-promoting factor 1 antibody, NEGF1 antibody, Neurite growth promoting factor 1 antibody, Neurite outgrowth-promoting factor, heparin-binding antibody, OSF-1 antibody, OSF1 antibody, Osteoblast-specific factor 1 antibody, pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1) antibody, Pleiotrophin antibody, PTN antibody, PTN_HUMAN antibody

UniProt: P21246

Pathways: RTK Signaling