PHF1 antibody (AA 151-360)

Catalog No. ABIN7163042

Product Details anti-PHF1 Antibody

Target: PHF1 (PHD Finger Protein 1 (PHF1))

Binding Specificity: AA 151-360

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PHF1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human PHD finger protein 10 protein (151-360AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PHF1

Target: PHF1 (PHD Finger Protein 1 (PHF1))

Alternative Name: PHF1 (PHF1 Products)

Synonyms: pcl1 antibody, xpcl1 antibody, MTF2L2 antibody, PCL1 antibody, PHF2 antibody, TDRD19C antibody, hPHF1 antibody, AW557215 antibody, D17Ertd455e antibody, Tctex-3 antibody, Tctex3 antibody, mPcl1 antibody, PHD finger protein 1 L homeolog antibody, PHD finger protein 1 antibody, phf1.L antibody, PHF1 antibody, Phf1 antibody

Background:

Background: Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).

Aliases: BAF45a antibody, BRG1-associated factor 45a antibody, FLJ10975 antibody, MGC111009 antibody, PHD finger protein 10 antibody, PHD finger protein 10, isoform a antibody, PHD zinc finger protein XAP135 antibody, Phf10 antibody, PHF10_HUMAN antibody, XAP135 antibody

UniProt: Q8WUB8