PCID2 antibody (AA 2-250) (HRP)

Catalog No. ABIN7162713

Product Details anti-PCID2 Antibody (HRP)

Target: PCID2 (PCI Domain Containing 2 (PCID2))

Binding Specificity: AA 2-250

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PCID2 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human PCI domain-containing protein 2 protein (2-250AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PCID2

Target: PCID2 (PCI Domain Containing 2 (PCID2))

Alternative Name: PCID2 (PCID2 Products)

Synonyms: F10 antibody, RGD1307041 antibody, A730042J05Rik antibody, ik:tdsubc_1e10 antibody, im:6909928 antibody, wu:fa11f03 antibody, xx:tdsubc_1e10 antibody, zgc:101845 antibody, PCI domain containing 2 antibody, PCI domain containing 2 S homeolog antibody, PCID2 antibody, Pcid2 antibody, pcid2.S antibody, pcid2 antibody

Background:

Background: Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells.

Aliases: CSN12 like protein antibody, CSN12-like protein antibody, DKFZp686C20226 antibody, F10 antibody, FLJ11305 antibody, FLJ99362 antibody, HT004 antibody, MGC16774 antibody, PCI domain containing 2 antibody, PCI domain containing protein 2 antibody, PCI domain-containing protein 2 antibody, PCID2 antibody, PCID2_HUMAN antibody, RP11 - 98F14.6 antibody

UniProt: Q5JVF3