PAN2 antibody (AA 628-908)

Catalog No. ABIN7162471

Product Details anti-PAN2 Antibody

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Binding Specificity: AA 628-908

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PAN2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human PAB-dependent poly(A)-specific ribonuclease subunit PAN2 protein (628-908AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PAN2

Target: PAN2 (PAN2 Poly(A) Specific Ribonuclease Subunit Homolog (PAN2))

Alternative Name: PAN2 (PAN2 Products)

Synonyms: USP52 antibody, 1200014O24Rik antibody, AI047843 antibody, AW742773 antibody, Usp52 antibody, mKIAA0710 antibody, PAN2 antibody, pan2 antibody, PAN2 poly(A) specific ribonuclease subunit antibody, PAN2 poly(A) specific ribonuclease subunit homolog (S. cerevisiae) antibody, PAN2 poly(A) specific ribonuclease subunit S homeolog antibody, PAN2 antibody, Pan2 antibody, pan2.S antibody

Background:

Background: Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3\\\'-5\\\' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5\\\'-3\\\' exonucleolytic degradation by XRN1.

Aliases: hPan2 antibody, Inactive ubiquitin carboxyl terminal hydrolase 52 antibody, Inactive ubiquitin carboxyl-terminal hydrolase 52 antibody, KIAA0710 antibody, PAB dependent poly(A) specific ribonuclease subunit 2 antibody, PAB-dependent poly(A)-specific ribonuclease subunit 2 antibody, PABP dependent poly(A) nuclease 2 antibody, PAN 2 antibody, PAN2 antibody, PAN2 homolog PABP1 dependent poly A specific ribonuclease subunit antibody, PAN2 poly(A) specific ribonuclease subunit homolog antibody, PAN2 polyA specific ribonuclease subunit homolog antibody, PAN2_HUMAN antibody, Ubiquitin specific peptidase 52 antibody, Ubiquitin specific protease 52 antibody, USP 52 antibody, USP52 antibody

UniProt: Q504Q3