OLR1 antibody (AA 58-273)
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- Target See all OLR1 Antibodies
- OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
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Binding Specificity
- AA 58-273
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This OLR1 antibody is un-conjugated
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Application
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- Cross-Reactivity
- Human, Rat
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human Oxidized low-density lipoprotein receptor 1 protein (58-273AA)
- Isotype
- IgG
- Top Product
- Discover our top product OLR1 Primary Antibody
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- Application Notes
- Recommended dilution: WB:1:500-1:5000, IHC:1:1000-1:2000, IF:1:200-1:500,
- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- OLR1 (Oxidized Low Density Lipoprotein (Lectin-Like) Receptor 1 (OLR1))
- Alternative Name
- OLR1 (OLR1 Products)
- Synonyms
- OLR1 antibody, LOX1 antibody, Olr1 antibody, CLEC8A antibody, LOXIN antibody, SCARE1 antibody, SLOX1 antibody, LOX-1 antibody, SR-EI antibody, Scare1 antibody, Oldlr1 antibody, Oldr1 antibody, PLOX-1 antibody, oxidized low density lipoprotein receptor 1 antibody, oxidized low density lipoprotein (lectin-like) receptor 1 antibody, OLR1 antibody, Olr1 antibody
- Background
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Background: Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro-oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro-atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram-positive bacteria.
Aliases: C-type lectin domain family 8 member A antibody, CLEC8A antibody, hLOX 1 antibody, hLOX-1 antibody, Lectin like oxidized LDL receptor 1 antibody, Lectin like oxLDL receptor 1 antibody, Lectin type oxidized LDL receptor 1 antibody, Lectin-like oxidized LDL receptor 1 antibody, Lectin-like oxLDL receptor 1 antibody, Lectin-type oxidized LDL receptor 1 antibody, low density lipoprotein oxidized, receptor 1 antibody, LOX-1 antibody, LOXIN antibody, Olr1 antibody, OLR1_HUMAN antibody, Ox LDL receptor 1 antibody, Ox-LDL receptor 1 antibody, Oxidised low density lipoprotein (lectin like) receptor 1 antibody, Oxidized low density lipoprotein receptor 1 antibody, Oxidized low density lipoprotein receptor 1 soluble form antibody, Oxidized low-density lipoprotein receptor 1 antibody, OxLDL receptor 1 antibody, SCARE1 antibody, Scavenger receptor class E, member 1 antibody, SLOX1 antibody, soluble form antibody, SR-EI antibody
- UniProt
- P78380
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