NOD2 antibody (AA 460-733)

Catalog No. ABIN7162073

Product Details anti-NOD2 Antibody

Target: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Binding Specificity: AA 460-733

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOD2 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Nucleotide-binding oligomerization domain-containing protein 2 protein (460-733AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NOD2

Target: NOD2 (Nucleotide-Binding Oligomerization Domain Containing 2 (NOD2))

Alternative Name: NOD2 (NOD2 Products)

Synonyms: ACUG antibody, BLAU antibody, CARD15 antibody, CD antibody, CLR16.3 antibody, IBD1 antibody, NLRC2 antibody, NOD2B antibody, PSORAS1 antibody, Card15 antibody, F830032C23Rik antibody, Nlrc2 antibody, caspase recruitment domain 15 protein antibody, nucleotide binding oligomerization domain containing 2 antibody, nucleotide-binding oligomerization domain containing 2 antibody, TTHERM_01951320 antibody, NOD2 antibody, Nod2 antibody

Background:

Background: Involved in gastrointestinal immunity. Upon stimulation by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, binds the proximal adapter receptor-interacting RIPK2, which recruits ubiquitin ligases as XIAP, BIRC2, BIRC3 and the LUBAC complex, triggering activation of MAP kinases and activation of NF-kappa-B signaling. This in turn leads to the transcriptional activation of hundreds of genes involved in immune response. Required for MDP-induced NLRP1-dependent CASP1 activation and IL1B release in macrophages (PubMed:18511561).

Aliases: ACUG antibody, Arthrocutaneouveal granulomatosis antibody, BLAU antibody, CARD15 antibody, Caspase recruitment domain family, member 15 antibody, Caspase recruitment domain protein 15 antibody, Caspase recruitment domain-containing protein 15 antibody, CD antibody, CLR16.3 antibody, IBD1 antibody, Inflammatory bowel disease protein 1 antibody, LRR containing protein antibody, NLR family, CARD domain containing 2 antibody, NLRC2 antibody, NOD like receptor C2 antibody, NOD2 antibody, NOD2 protein antibody, NOD2_HUMAN antibody, NOD2B antibody, nucleotide binding oligomerization domain 2 antibody, Nucleotide binding oligomerization domain containing 2 antibody, Nucleotide binding oligomerization domain, leucine rich repeat and CARD domain containing 2 antibody, Nucleotide-binding oligomerization domain-containing protein 2 antibody, PSORAS1 antibody

UniProt: Q9HC29

Pathways: Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, Inflammasome