RORB antibody (AA 1-269)

Catalog No. ABIN7161877

Product Details anti-RORB Antibody

Target: RORB (RAR-Related Orphan Receptor B (RORB))

Binding Specificity: AA 1-269

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RORB antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Nuclear receptor ROR-beta protein (1-269AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RORB

Target: RORB (RAR-Related Orphan Receptor B (RORB))

Alternative Name: RORB (RORB Products)

Synonyms: RORB antibody, Nr1f2 antibody, LOC100226267 antibody, NR1F2 antibody, ROR-BETA antibody, RZR-BETA antibody, RZRB antibody, bA133M9.1 antibody, nr1f2 antibody, rzrb antibody, sb:eu943 antibody, RZR-beta antibody, Rorbeta antibody, RAR related orphan receptor B antibody, RAR-related orphan receptor B antibody, RAR-related orphan receptor beta antibody, RORB antibody, Rorb antibody, rorb antibody

Background:

Background: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5\'-AGGTCA-3\' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).

Aliases: bA133M9.1 antibody, NR1F2 antibody, Nuclear receptor ROR-beta antibody, Nuclear receptor RZR beta antibody, Nuclear receptor RZR-beta antibody, Nuclear receptor subfamily 1 group F member 2 antibody, OTTHUMP00000021486 antibody, RAR related orphan receptor B antibody, RAR related orphan receptor beta antibody, Retinoic acid binding receptor beta antibody, Retinoid-related orphan receptor-beta antibody, ROR BETA antibody, Rorb antibody, RORB_HUMAN antibody, RZR BETA antibody, RZRB antibody

UniProt: Q92753

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway