NCOA6 antibody (AA 285-504) (Biotin)

Catalog No. ABIN7161866

Product Details anti-NCOA6 Antibody (Biotin)

Target: NCOA6 (Nuclear Receptor Coactivator 6 (NCOA6))

Binding Specificity: AA 285-504

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA6 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Nuclear receptor coactivator 6 protein (285-504AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NCOA6

Target: NCOA6 (Nuclear Receptor Coactivator 6 (NCOA6))

Alternative Name: NCOA6 (NCOA6 Products)

Synonyms: gb:dq017635 antibody, wu:fb25d11 antibody, ncoa6 antibody, AIB3 antibody, ASC2 antibody, NRC antibody, PRIP antibody, RAP250 antibody, TRBP antibody, ASC-2 antibody, Ncoa7 antibody, mKIAA0181 antibody, Aib3 antibody, Trbp antibody, nuclear receptor coactivator 6 antibody, NCOA6 antibody, Tsp_14219 antibody, Tsp_13372 antibody, ncoa6 antibody, LOC100196047 antibody, Ncoa6 antibody

Background:

Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.

Aliases: NCOA6 antibody, AIB3 antibody, KIAA0181 antibody, RAP250 antibody, TRBP antibody, Nuclear receptor coactivator 6 antibody, Activating signal cointegrator 2 antibody, ASC-2 antibody, Amplified in breast cancer protein 3 antibody, Cancer-amplified transcriptional coactivator ASC-2 antibody, Nuclear receptor coactivator RAP250 antibody, NRC RAP250 antibody, Nuclear receptor-activating protein antibody, 250 kDa antibody, Peroxisome proliferator-activated receptor-interacting protein antibody, PPAR-interacting protein antibody, PRIP antibody, Thyroid hormone receptor-binding protein antibody

UniProt: Q14686

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Lipid Metabolism by PPARalpha