NCOA1 antibody (AA 284-393)

Catalog No. ABIN7161856

Product Details anti-NCOA1 Antibody

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Binding Specificity: AA 284-393

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCOA1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Nuclear receptor coactivator 1 protein (284-393AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NCOA1

Target: NCOA1 (Nuclear Receptor Coactivator 1 (NCOA1))

Alternative Name: NCOA1 (NCOA1 Products)

Synonyms: F-SRC-1 antibody, KAT13A antibody, RIP160 antibody, SRC1 antibody, bHLHe42 antibody, bHLHe74 antibody, si:dkey-5g7.6 antibody, si:dkey-34f16.6 antibody, NCOA1 antibody, SRC-1 antibody, nuclear receptor coactivator 1 antibody, NCOA1 antibody, ncoa1 antibody, Ncoa1 antibody

Background:

Background: Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Involved in the coactivation of different nuclear receptors, such as for steroids (PGR, GR and ER), retinoids (RXRs), thyroid hormone (TRs) and prostanoids (PPARs). Also involved in coactivation mediated by STAT3, STAT5A, STAT5B and STAT6 transcription factors. Displays histone acetyltransferase activity toward H3 and H4, the relevance of such activity remains however unclear. Plays a central role in creating multisubunit coactivator complexes that act via remodeling of chromatin, and possibly acts by participating in both chromatin remodeling and recruitment of general transcription factors. Required with NCOA2 to control energy balance between white and brown adipose tissues. Required for mediating steroid hormone response. Isoform 2 has a higher thyroid hormone-dependent transactivation activity than isoform 1 and isoform 3.

Aliases: bHLHe74 antibody, Class E basic helix-loop-helix protein 74 antibody, F SRC 1 antibody, Hin 2 protein antibody, Hin2 protein antibody, MGC129719 antibody, MGC129720 antibody, mNRC 1 antibody, NCoA 1 antibody, NCoA-1 antibody, Ncoa1 antibody, NCOA1_HUMAN antibody, Nuclear receptor coactivator 1 antibody, Nuclear receptor coactivator protein 1 antibody, NY REN 52 antigen antibody, Protein Hin 2 antibody, Protein Hin-2 antibody, Protein Hin2 antibody, Renal carcinoma antigen NY REN 52 antibody, Renal carcinoma antigen NY-REN-52 antibody, RIP 160 antibody, RIP160 antibody, SRC 1 antibody, SRC-1 antibody, Steroid receptor coactivator 1 antibody

UniProt: Q15788

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha