NUPR1 antibody (AA 2-64)

Catalog No. ABIN7161848

Product Details anti-NUPR1 Antibody

Target: NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))

Binding Specificity: AA 2-64

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUPR1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Nuclear protein 1 protein (2-64AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NUPR1

Target: NUPR1 (Nuclear Protein, Transcriptional Regulator, 1 (NUPR1))

Alternative Name: NUPR1 (NUPR1 Products)

Synonyms: COM1 antibody, P8 antibody, 2310032H04Rik antibody, Com1 antibody, p8 antibody, nuclear protein 1, transcriptional regulator antibody, nuclear protein transcription regulator 1 antibody, NUPR1 antibody, Nupr1 antibody

Background:

Background: Chromatin-binding protein that converts stress signals into a program of gene expression that empowers cells with resistance to the stress induced by a change in their microenvironment. Interacts with MSL1 and inhibits its activity on histone H4 \'Lys-16\' acetylation (H4K16ac). Binds the RELB promoter and activates its transcription, leading to the transactivation of IER3. The NUPR1/RELB/IER3 survival pathway may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment. In breast cancer cells, NUPR1 overexpression leads to the activation of PI3K/AKT signaling pathway, CDKN1A/p21 phosphorylation and relocalization from the nucleus to the cytoplasm, leading to resistance to chemotherapeutic agents, such as doxorubicin.

Aliases: Candidate of metastasis 1 antibody, COM1 antibody, Nuclear protein 1 antibody, Nupr1 antibody, NUPR1_HUMAN antibody, p8 protein antibody, Protein p8 antibody

UniProt: O60356