TNIK antibody (pSer764)

Catalog No. ABIN711941

Product Details anti-TNIK Antibody

Target: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Binding Specificity: pSer764

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNIK antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Specificity: Phosphorylation site corresponds to Ser735 in mouse

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human TNIK around the phosphorylation site of Ser764

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for TNIK

Target: TNIK (TRAF2 and NCK Interacting Kinase (TNIK))

Alternative Name: TNIK (TNIK Products)

Synonyms: RGD1561817 antibody, TNIK antibody, 1500031A17Rik antibody, 4831440I19Rik antibody, AI451411 antibody, C530008O15Rik antibody, C630040K21Rik antibody, fc52d11 antibody, msn antibody, tnikl antibody, wu:fc52d11 antibody, zgc:63535 antibody, im:6898857 antibody, zgc:123033 antibody, zgc:152783 antibody, tnik antibody, TRAF2 and NCK interacting kinase antibody, TRAF2 and NCK interacting kinase a antibody, TRAF2 and NCK interacting kinase b antibody, TRAF2 and NCK interacting kinase S homeolog antibody, TNIK antibody, Tnik antibody, tnika antibody, tnikb antibody, tnik.S antibody

Background:

Synonyms: TRAF2 and NCK-interacting protein kinase, TNIK, KIAA0551

Background: Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322.

Gene ID: 23043

UniProt: Q9UKE5