NMNAT1 antibody (AA 1-279)

Catalog No. ABIN7161578

Product Details anti-NMNAT1 Antibody

Target: NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1))

Binding Specificity: AA 1-279

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NMNAT1 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 protein (1-279AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NMNAT1

Target: NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1))

Alternative Name: NMNAT1 (NMNAT1 Products)

Background:

Background: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form, nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, prefers NAD(+) and NaAD as substrates and degrades NADH, nicotinic acid adenine dinucleotide phosphate (NHD) and nicotinamide guanine dinucleotide (NGD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Protects against axonal degeneration following mechanical or toxic insults.

Aliases: EC 2.7.7.1 antibody, LCA9 antibody, Leber's congenital amaurosis 9 antibody, NaMN adenylyltransferase 1 antibody, nicotinamide nucleotide adenylyltransferase 1 antibody, Nicotinamide-nucleotide adenylyltransferase 1 antibody, Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 antibody, nicotinate nucleotide adenylyltransferase 1 antibody, Nicotinate-nucleotide adenylyltransferase 1 antibody, NMN adenylyltransferase 1 antibody, NMN/NaMN adenylyltransferase 1 antibody, NMNA1_HUMAN antibody, Nmnat 1 antibody, Nmnat1 antibody, OTTHUMP00000001731 antibody, OTTHUMP00000001732 antibody, OTTHUMP00000035892 antibody, PNAT 1 antibody, PNAT1 antibody, pyridine nucleotide adenylyltransferase 1 antibody

UniProt: Q9HAN9