NEUROD2 antibody (AA 254-339)

Catalog No. ABIN7161286

Product Details anti-NEUROD2 Antibody

Target: NEUROD2 (Neurogenic Differentiation 2 (NEUROD2))

Binding Specificity: AA 254-339

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NEUROD2 antibody is un-conjugated

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Neurogenic differentiation factor 2 protein (254-339AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NEUROD2

Target: NEUROD2 (Neurogenic Differentiation 2 (NEUROD2))

Alternative Name: NEUROD2 (NEUROD2 Products)

Synonyms: NEUROD2 antibody, ndrf antibody, MGC145932 antibody, Ndrf antibody, bHLHa1 antibody, ndr2 antibody, wu:fj49a11 antibody, zNdr2 antibody, NDRF antibody, neuronal differentiation 2 antibody, neurogenic differentiation 2 antibody, NEUROD2 antibody, neurod2 antibody, Neurod2 antibody

Background:

Background: Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation, prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections, involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter (By similarity).

Aliases: bHLHa1 antibody, class A basic helix loop helix protein 1 antibody, Class A basic helix-loop-helix protein 1 antibody, NDF2_HUMAN antibody, NDR2 antibody, NDRF antibody, neuroD related factor antibody, NeuroD-related factor antibody, NeuroD2 antibody, neurogenic basic helix loop helix protein antibody, neurogenic differentiation 2 antibody, Neurogenic differentiation factor 2 antibody, neuronal differentiation 2 antibody

UniProt: Q15784