C19orf46 antibody (AA 1-242)

Catalog No. ABIN7161174

Product Details anti-C19orf46 Antibody

Target: C19orf46 (Chromosome 19 Open Reading Frame 46 (C19orf46))

Binding Specificity: AA 1-242

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C19orf46 antibody is un-conjugated

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Nesprin-4 protein (1-242AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for C19orf46

Target: C19orf46 (Chromosome 19 Open Reading Frame 46 (C19orf46))

Alternative Name: SYNE4 (C19orf46 Products)

Synonyms: C19orf46 antibody, Nesp4 antibody, C18H19orf46 antibody, 0610012K07Rik antibody, AI428936 antibody, RGD1304580 antibody, C1H19orf46 antibody, spectrin repeat containing nuclear envelope family member 4 antibody, spectrin repeat containing, nuclear envelope family member 4 antibody, SYNE4 antibody, Syne4 antibody

Background:

Background: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex, involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Behaves as a kinesin cargo, providing a functional binding site for kinesin-1 at the nuclear envelope. Hence may contribute to the establishment of secretory epithelial morphology by promoting kinesin-dependent apical migration of the centrosome and Golgi apparatus and basal localization of the nucleus.

Aliases: SYNE4 antibody, C19orf46 antibody, Nesprin-4 antibody, KASH domain-containing protein 4 antibody, KASH4 antibody, Nuclear envelope spectrin repeat protein 4 antibody

UniProt: Q8N205