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SYNE2 antibody (AA 1-176)

SYNE2 Reactivity: Human ELISA, IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7161170
  • Target See all SYNE2 Antibodies
    SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))
    Binding Specificity
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-176
    Reactivity
    • 14
    • 4
    • 1
    Human
    Host
    • 12
    • 4
    Rabbit
    Clonality
    • 12
    • 4
    Polyclonal
    Conjugate
    • 12
    • 2
    • 1
    • 1
    This SYNE2 antibody is un-conjugated
    Application
    • 10
    • 7
    • 5
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Nesprin-2 protein (1-176AA)
    Isotype
    IgG
    Top Product
    Discover our top product SYNE2 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    SYNE2 (Spectrin Repeat Containing, Nuclear Envelope 2 (SYNE2))
    Alternative Name
    SYNE2 (SYNE2 Products)
    Synonyms
    EDMD5 antibody, NUA antibody, NUANCE antibody, Nesp2 antibody, Nesprin-2 antibody, SYNE-2 antibody, TROPH antibody, SYNE2 antibody, nua antibody, edmd5 antibody, nuance antibody, syne-2 antibody, nesprin-2 antibody, 6820443O06Rik antibody, AW546258 antibody, D12Ertd777e antibody, Nesp2g antibody, mKIAA1011 antibody, RGD1305248 antibody, spectrin repeat containing nuclear envelope protein 2 antibody, spectrin repeat containing, nuclear envelope 2 antibody, SYNE2 antibody, syne2 antibody, Syne2 antibody
    Background

    Background: Multi-isomeric modular protein which forms a linking network between organelles and the actin cytoskeleton to maintain the subcellular spatial organization. As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Specifically, SYNE2 and SUN2 assemble in arrays of transmembrane actin-associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow during actin-dependent nuclear movement. May be involved in nucleus-centrososme attachment. During interkinetic nuclear migration (INM) at G2 phase and nuclear migration in neural progenitors its LINC complex association with SUN1/2 and probable association with cytoplasmic dynein-dynactin motor complexes functions to pull the nucleus toward the centrosome, SYNE1 and SYNE2 may act redundantly. During INM at G1 phase mediates respective LINC complex association with kinesin to push the nucleus away from the centrosome. Involved in nuclear migration in retinal photoreceptor progenitors. Required for centrosome migration to the apical cell surface during early ciliogenesis.

    Aliases: DKFZP434H2235 antibody, DKFZp686E01115 antibody, DKFZp686H1931 antibody, FLJ11014 antibody, FLJ43727 antibody, FLJ45710 antibody, FLJ46790 antibody, KIAA1011 antibody, Nesprin-2 antibody, Nesprin2 antibody, NUA antibody, NUANCE antibody, Nuclear envelope spectrin repeat protein 2 antibody, Nucleus and actin connecting element antibody, Nucleus and actin connecting element protein antibody, Protein NUANCE antibody, Spectrin repeat containing nuclear envelope 2 antibody, Synaptic nuclear envelope protein 2 antibody, Synaptic nuclei expressed gene 2 antibody, SYNE 2 antibody, Syne-2 antibody, SYNE2 antibody, SYNE2_HUMAN antibody

    UniProt
    Q8WXH0
    Pathways
    Maintenance of Protein Location
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