NPHP4 antibody (AA 397-543) (Biotin)

Catalog No. ABIN7161159

Product Details anti-NPHP4 Antibody (Biotin)

Target: NPHP4 (Nephronophthisis 4 (NPHP4))

Binding Specificity: AA 397-543

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NPHP4 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Nephrocystin-4 protein (397-543AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NPHP4

Target: NPHP4 (Nephronophthisis 4 (NPHP4))

Alternative Name: NPHP4 (NPHP4 Products)

Synonyms: NPHP4 antibody, POC10 antibody, SLSN4 antibody, 4930564O18Rik antibody, nmf192 antibody, nephrocystin 4 antibody, nephrocystin-4 antibody, nephronophthisis 4 (juvenile) homolog (human) antibody, NPHP4 antibody, LOC100184720 antibody, Nphp4 antibody

Background:

Background: Involved in the organization of apical junctions, the function is proposed to implicate a NPHP1-4-8 module (PubMed:19755384, PubMed:21565611). Does not seem to be strictly required for ciliogenesis (PubMed:21565611). Required for building functional cilia. Involved in the organization of the subapical actin network in multiciliated epithelial cells. Seems to recruit INT to basal bodies of motile cilia which subsequently interacts with actin-modifying proteins such as DAAM1 (By similarity). In cooperation with INVS may downregulate the canonical Wnt pathway and promote the Wnt-PCP pathway by regulating expression and subcellular location of disheveled proteins. Stabilizes protein levels of JADE1 and promotes its translocation to the nucleus leading to cooperative inhibition of canonical Wnt signaling (PubMed:21498478, PubMed:22654112). Acts as negative regulator of the hippo pathway by association with LATS1 and modifying LATS1-dependent phosphorylation and localization of WWTR1/TAZ (PubMed:21555462).

Aliases: KIAA0673 antibody, Nephrocystin-4 antibody, nephronophthisis 4 antibody, Nephroretinin antibody, NPHP4 antibody, NPHP4_HUMAN antibody, POC10 antibody, POC10 centriolar protein homolog antibody, SLSN4 antibody

UniProt: O75161