NCR3 antibody (AA 19-135) (HRP)

Catalog No. ABIN7161083

Product Details anti-NCR3 Antibody (HRP)

Target: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Binding Specificity: AA 19-135

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NCR3 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Natural cytotoxicity triggering receptor 3 protein (19-135AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NCR3

Target: NCR3 (Natural Cytotoxicity Triggering Receptor 3 (NCR3))

Alternative Name: NCR3 (NCR3 Products)

Synonyms: MGC133750 antibody, 1C7 antibody, CD337 antibody, LY117 antibody, MALS antibody, NKp30 antibody, Nkp30 antibody, natural cytotoxicity triggering receptor 3 antibody, NCR3 antibody, Ncr3 antibody

Background:

Background: Cell membrane receptor of natural killer/NK cells that is activated by binding of extracellular ligands including BAG6 and NCR3LG1. Stimulates NK cells cytotoxicity toward neighboring cells producing these ligands. It controls, for instance, NK cells cytotoxicity against tumor cells. Engagement of NCR3 by BAG6 also promotes myeloid dendritic cells (DC) maturation, both through killing DCs that did not acquire a mature phenotype, and inducing the release by NK cells of TNFA and IFNG which promote DC maturation.

Aliases: 1C7 antibody, Activating natural killer receptor p30 antibody, Activating NK A1 receptor antibody, CD337 antibody, CD337 antigen antibody, LY117 antibody, Lymphocyte antigen 117 antibody, MALS antibody, Natural cytotoxicity triggering receptor 3 antibody, Natural killer cell p30 related protein antibody, Natural killer cell p30-related protein antibody, Ncr3 antibody, NCTR3_HUMAN antibody, NK-p30 antibody, NKp30 antibody

UniProt: O14931

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process