SIRT5 antibody (AA 60-212)

Catalog No. ABIN7160870

Product Details anti-SIRT5 Antibody

Target: SIRT5 (Sirtuin 5 (SIRT5))

Binding Specificity: AA 60-212

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT5 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human NAD-dependent protein deacylase sirtuin-5, mitochondrial protein (60-212AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SIRT5

Target: SIRT5 (Sirtuin 5 (SIRT5))

Alternative Name: SIRT5 (SIRT5 Products)

Synonyms: SIR2L5 antibody, 0610012J09Rik antibody, 1500032M05Rik antibody, AV001953 antibody, zgc:92288 antibody, sirt5-a antibody, SIRT5 antibody, sir2l5 antibody, sirtuin 5 antibody, sirtuin 5 L homeolog antibody, SIRT5 antibody, Sirt5 antibody, sirt5 antibody, sirt5.L antibody, CC1G_00083 antibody

Background:

Background: NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins (PubMed:21908771, PubMed:22076378, PubMed:24703693). Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting: acts by mediating desuccinylation and deglutarylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting (PubMed:22076378, PubMed:24703693). Activates SOD1 by mediating its desuccinylation, leading to reduced reactive oxygen species (PubMed:24140062). Modulates ketogenesis through the desuccinylation and activation of HMGCS2 (By similarity). Has weak NAD-dependent protein deacetylase activity, however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro such as UOX.

Aliases: NAD dependent deacetylase sirtuin 5 antibody, NAD dependent lysine demalonylase and desuccinylase sirtuin 5 mitochondrial antibody, NAD dependent protein deacylase sirtuin 5 mitochondrial antibody, NAD-dependent protein deacylase sirtuin-5, mitochondrial antibody, Regulatory protein SIR2 homolog 5 antibody, Silent mating type information regulation 2 S.cerevisiae homolog 5 antibody, Sir2 like 5 antibody, SIR2-like protein 5 antibody, SIR2L5 antibody, SIR5_HUMAN antibody, Sirt5 antibody, Sirtuin 5 antibody, Sirtuin type 5 antibody

UniProt: Q9NXA8

Pathways: SARS-CoV-2 Protein Interactome