SIRT7 antibody (AA 242-379)

Catalog No. ABIN7160866

Product Details anti-SIRT7 Antibody

Target: SIRT7 (Sirtuin 7 (SIRT7))

Binding Specificity: AA 242-379

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIRT7 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human NAD-dependent protein deacetylase sirtuin-7 protein (242-379AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SIRT7

Target: SIRT7 (Sirtuin 7 (SIRT7))

Alternative Name: SIRT7 (SIRT7 Products)

Synonyms: SIRT7 antibody, LOC796135 antibody, SIR2L7 antibody, sirtuin 7 antibody, phosphate cytidylyltransferase 2, ethanolamine antibody, SIRT7 antibody, sirt7 antibody, PCYT2 antibody, Sirt7 antibody

Background:

Background: NAD-dependent protein deacetylase that specifically mediates deacetylation of histone H3 at \'Lys-18\' (H3K18Ac). In contrast to other histone deacetylases, displays selectivity for a single histone mark, H3K18Ac, directly linked to control of gene expression. H3K18Ac is mainly present around the transcription start site of genes and has been linked to activation of nuclear hormone receptors. SIRT7 thereby acts as a transcription repressor. Moreover, H3K18 hypoacetylation has been reported as a marker of malignancy in various cancers and seems to maintain the transformed phenotype of cancer cells. These data suggest that SIRT7 may play a key role in oncogenic transformation by suppresses expression of tumor suppressor genes by locus-specific deacetylation of H3K18Ac at promoter regions. Also required to restore the transcription of ribosomal RNA (rRNA) at the exit from mitosis: promotes the association of RNA polymerase I with the rDNA promoter region and coding region. Stimulates transcription activity of the RNA polymerase I complex. May also deacetylate p53/TP53 and promotes cell survival, however such data need additional confirmation.

Aliases: NAD dependent deacetylase sirtuin 7 antibody, NAD dependent protein deacetylase sirtuin 7 antibody, NAD-dependent protein deacetylase sirtuin-7 antibody, Regulatory protein SIR2 homolog 7 antibody, Silent mating type information regulation 2 homolog antibody, Silent mating type information regulation 2 S.cerevisiae homolog 7 antibody, SIR2 L7 antibody, SIR2 like protein 7 antibody, Sir2 related protein type 7 antibody, SIR2, S.CEREVISIAE, HOMOLOG-LIKE 7 antibody, SIR2-like protein 7 antibody, SIR2L 7 antibody, SIR2L7 antibody, SIR7_HUMAN antibody, SIRT 7 antibody, SIRT7 antibody, Sirtuin 7 antibody, Sirtuin type 7 antibody, Sirtuin7 antibody

UniProt: Q9NRC8