NLRP1 antibody (AA 1-146) (HRP)

Catalog No. ABIN7160820

Product Details anti-NLRP1 Antibody (HRP)

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Binding Specificity: AA 1-146

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NLRP1 antibody is conjugated to HRP

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human NACHT, LRR and PYD domains-containing protein 1 protein (1-146AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NLRP1

Target: NLRP1 (NLR Family, Pyrin Domain Containing 1 (NLRP1))

Alternative Name: NLRP1 (NLRP1 Products)

Synonyms: CARD7 antibody, CIDED antibody, CLR17.1 antibody, DEFCAP antibody, DEFCAP-L/S antibody, NAC antibody, NALP1 antibody, PP1044 antibody, SLEV1 antibody, VAMAS1 antibody, NLR family pyrin domain containing 1 antibody, NLRP1 antibody, Nlrp1 antibody

Background:

Background: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitement of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death (PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide (MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner (PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin (PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release (PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP (PubMed:17349957). Binds ATP (PubMed:11113115, PubMed:15212762).

Aliases: CARD 7 antibody, CARD7 antibody, Caspase recruitment domain protein 7 antibody, Caspase recruitment domain-containing protein 7 antibody, CLR17.1 antibody, Death effector filament forming Ced 4 like apoptosis protein antibody, Death effector filament-forming ced-4-like apoptosis protein antibody, DEFCAP antibody, DEFCAP L/S antibody, DKFZp586O1822 antibody, KIAA0926 antibody, LRR and PYD domains-containing protein 1 antibody, NAC alpha/beta/gamma/delta antibody, NAC antibody, NACHT antibody, NACHT leucine rich repeat and PYD containing 1 antibody, NACHT leucine rich repeat and PYD pyrin domain containing 1 antibody, NACHT leucine rich repeat and pyrin domain containing 1 antibody, NACHT LRR and PYD containing protein 1 antibody, NALP 1 antibody, NALP1 antibody, NALP1_HUMAN antibody, NLR family pyrin domain containing 1 antibody, NLRP 1 antibody, NLRP1 antibody, NLRP1 protein antibody, Nucleotide binding domain and caspase recruitment domain antibody, Nucleotide binding oligomerization domain leucine rich repeat and pyrin domain containing 1 antibody, Nucleotide-binding domain and caspase recruitment domain antibody, PP 1044 antibody, PP1044 antibody

UniProt: Q9C000

Pathways: Positive Regulation of Endopeptidase Activity, Inflammasome