GPR18 antibody (AA 290-331) (FITC)
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- Target See all GPR18 Antibodies
- GPR18 (G Protein-Coupled Receptor 18 (GPR18))
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Binding Specificity
- AA 290-331
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Reactivity
- Human
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Host
- Rabbit
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Clonality
- Polyclonal
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Conjugate
- This GPR18 antibody is conjugated to FITC
- Application
- Please inquire
- Cross-Reactivity
- Human
- Purification
- >95%, Protein G purified
- Immunogen
- Recombinant Human N-arachidonyl glycine receptor protein (290-331AA)
- Isotype
- IgG
- Top Product
- Discover our top product GPR18 Primary Antibody
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Buffer
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Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4 - Preservative
- ProClin
- Precaution of Use
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Storage
- -20 °C,-80 °C
- Storage Comment
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- Target
- GPR18 (G Protein-Coupled Receptor 18 (GPR18))
- Alternative Name
- GPR18 (GPR18 Products)
- Synonyms
- GPR18 antibody, G protein-coupled receptor 18 antibody, GPR18 antibody, Gpr18 antibody
- Background
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Background: Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937). However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161). Can also be activated by plant-derived and synthetic cannabinoid agonists (PubMed:24762058). The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083). May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs)in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity). Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity). Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937).
Aliases: GPR18 antibody, GPCRWN-arachidonyl glycine receptor antibody, NAGly receptor antibody, G-protein coupled receptor 18 antibody
- UniProt
- Q14330
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