MEF2C antibody (AA 170-380)

Catalog No. ABIN7160504

Product Details anti-MEF2C Antibody

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Binding Specificity: AA 170-380

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MEF2C antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Myocyte-specific enhancer factor 2C protein (170-380AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MEF2C

Target: MEF2C (Myocyte Enhancer Factor 2C (MEF2C))

Alternative Name: MEF2C (MEF2C Products)

Synonyms: MEF2C antibody, XMEF2C antibody, si:ch211-202e12.2 antibody, C5DELq14.3 antibody, DEL5q14.3 antibody, 5430401D19Rik antibody, 9930028G15Rik antibody, AV011172 antibody, Mef2 antibody, RGD1563119 antibody, id:ibd5026 antibody, mef2c antibody, wu:fc05b06 antibody, zgc:64184 antibody, zgc:85726 antibody, myocyte enhancer factor 2C antibody, MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) antibody, myocyte enhancer factor 2cb antibody, MADS box transcription enhancer factor 2, polypeptide C (myocyte enhancer factor 2C) L homeolog antibody, myocyte enhancer factor 2ca antibody, MEF2C antibody, mef2c antibody, mef2cb antibody, mef2c.L antibody, Mef2c antibody, mef2ca antibody

Background:

Background: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.

Aliases: C5DELq14.3 antibody, DEL5q14.3 antibody, MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody, MADS box transcription enhancer factor 2, polypeptide C antibody, MEF2C antibody, MEF2C_HUMAN antibody, Myocyte enhancer factor 2C antibody, Myocyte specific enhancer factor 2C antibody, Myocyte-specific enhancer factor 2C antibody, OTTHUMP00000222409 antibody, Similar to MADS box transcription enhancer factor 2 polypeptide C antibody

UniProt: Q06413

Pathways: Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Chromatin Binding, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Toll-Like Receptors Cascades, BCR Signaling