SMAD2 antibody (AA 2-467)

Catalog No. ABIN7160228

Product Details anti-SMAD2 Antibody

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Binding Specificity: AA 2-467

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SMAD2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mothers against decapentaplegic homolog 2 protein (2-467AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:5000, IHC:1:100-1:1000, IF:1:50-1:500,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for SMAD2

Target: SMAD2 (SMAD, Mothers Against DPP Homolog 2 (SMAD2))

Alternative Name: SMAD2 (SMAD2 Products)

Synonyms: JV18 antibody, JV18-1 antibody, MADH2 antibody, MADR2 antibody, hMAD-2 antibody, hSMAD2 antibody, jv18 antibody, Xmad2 antibody, madh2 antibody, madr2 antibody, XSmad2 antibody, hmad-2 antibody, hsmad2 antibody, jv18-1 antibody, smad-2 antibody, fj43c06 antibody, wu:fj43c06 antibody, 7120426M23Rik antibody, Madh2 antibody, Madr2 antibody, Smad-2 antibody, mMad2 antibody, MAD homolog 2 antibody, Mothers against DPP homolog 2 antibody, SMAD 2 antibody, Smad2 antibody, SMAD family member 2 antibody, SMAD family member 2-Z antibody, SMAD family member 2 S homeolog antibody, SMAD2 antibody, SMAD2Z antibody, smad2 antibody, smad2.S antibody, Smad2 antibody

Background:

Background: Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Aliases: Drosophila, homolog of, MADR2 antibody, hMAD-2 antibody, HsMAD2 antibody, JV18 antibody, JV18-1 antibody, JV181 antibody, MAD antibody, MAD homolog 2 antibody, MAD Related Protein 2 antibody, Mad-related protein 2 antibody, MADH2 antibody, MADR2 antibody, MGC22139 antibody, MGC34440 antibody, Mother against DPP homolog 2 antibody, Mothers against decapentaplegic homolog 2 antibody, Mothers against decapentaplegic, Drosophila, homolog of, 2 antibody, Mothers against DPP homolog 2 antibody, OTTHUMP00000163489 antibody, Sma and Mad related protein 2 antibody, Sma- and Mad-related protein 2 MAD antibody, SMAD 2 antibody, SMAD family member 2 antibody, SMAD, mothers against DPP homolog 2 antibody, SMAD2 antibody, SMAD2_HUMAN antibody

UniProt: Q15796

Pathways: Cell Division Cycle, Hormone Transport, Chromatin Binding, Protein targeting to Nucleus