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BUB1 antibody (AA 256-577)

BUB1 Reactivity: Human ELISA, IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7160084
  • Target See all BUB1 Antibodies
    BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))
    Binding Specificity
    • 15
    • 8
    • 6
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 256-577
    Reactivity
    • 70
    • 27
    • 7
    • 1
    Human
    Host
    • 60
    • 11
    Rabbit
    Clonality
    • 60
    • 11
    Polyclonal
    Conjugate
    • 42
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This BUB1 antibody is un-conjugated
    Application
    • 55
    • 30
    • 16
    • 13
    • 13
    • 13
    • 10
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC)
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Mitotic checkpoint serine/threonine-protein kinase BUB1 protein (256-577AA)
    Isotype
    IgG
    Top Product
    Discover our top product BUB1 Primary Antibody
  • Application Notes
    Recommended dilution: IHC:1:20-1:200,
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    BUB1 (Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1))
    Alternative Name
    BUB1 (BUB1 Products)
    Synonyms
    bub1a antibody, bub1l antibody, hbub1 antibody, xbub1 antibody, BUB1A antibody, BUB1L antibody, hBUB1 antibody, AL022991 antibody, Bub1a antibody, C80208 antibody, D2Xrf87 antibody, BUB1 mitotic checkpoint serine/threonine kinase antibody, BUB1, mitotic checkpoint serine/threonine kinase antibody, BUB1 antibody, bub1 antibody, Bub1 antibody
    Background

    Background: Serine/threonine-protein kinase that performs 2 crucial functions during mitosis: it is essential for spindle-assembly checkpoint signaling and for correct chromosome alignment. Has a key role in the assembly of checkpoint proteins at the kinetochore, being required for the subsequent localization of CENPF, BUB1B, CENPE and MAD2L1. Required for the kinetochore localization of PLK1. Plays an important role in defining SGO1 localization and thereby affects sister chromatid cohesion. Acts as a substrate for anaphase-promoting complex or cyclosome (APC/C) in complex with its activator CDH1 (APC/C-Cdh1). Necessary for ensuring proper chromosome segregation and binding to BUB3 is essential for this function. Can regulate chromosome segregation in a kinetochore-independent manner. Can phosphorylate BUB3. The BUB1-BUB3 complex plays a role in the inhibition of APC/C when spindle-assembly checkpoint is activated and inhibits the ubiquitin ligase activity of APC/C by phosphorylating its activator CDC20. This complex can also phosphorylate MAD1L1. Kinase activity is essential for inhibition of APC/CCDC20 and for chromosome alignment but does not play a major role in the spindle-assembly checkpoint activity. Mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis.

    Aliases: Bub1 antibody, BUB1 budding uninhibited by benzimidazoles 1 homolog antibody, BUB1 budding uninhibited by benzimidazoles 1 homolog (yeast) antibody, BUB1 mitotic checkpoint serine/threonine kinase antibody, BUB1, S. cerevisiae, homolog of antibody, BUB1_HUMAN antibody, BUB1A antibody, BUB1L antibody, Budding uninhibited by benzimidazoles 1 (yeast homolog) antibody, Budding uninhibited by benzimidazoles 1 homolog antibody, Budding uninhibited by benzimidazoles 1, S. cerevisiae, homolog of antibody, hBUB1 antibody, Homolog of mitotic checkpoint gene BUB1 antibody, Mitotic checkpoint gene BUB1 antibody, Mitotic checkpoint serine/threonine protein kinase BUB1 antibody, Mitotic checkpoint serine/threonine-protein kinase BUB1 antibody, Mitotic spindle checkpoint kinase antibody, Putative serine/threonine protein kinase antibody

    UniProt
    O43683
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