MAPK7 antibody (AA 1-310)

Catalog No. ABIN7160008

Product Details anti-MAPK7 Antibody

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Binding Specificity: AA 1-310

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAPK7 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Mitogen-activated protein kinase 7 protein (1-310AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for MAPK7

Target: MAPK7 (Mitogen-Activated Protein Kinase 7 (MAPK7))

Alternative Name: MAPK7 (MAPK7 Products)

Synonyms: BMK1 antibody, ERK4 antibody, ERK5 antibody, PRKM7 antibody, Erk5-T antibody, ATMPK7 antibody, F8D23.5 antibody, F8D23_5 antibody, MAP kinase 7 antibody, Bmk1 antibody, Erk5 antibody, Prkm7 antibody, ERK-5 antibody, bmk1 antibody, erk4 antibody, mapk7 antibody, prkm7 antibody, mitogen-activated protein kinase 7 antibody, MAP kinase 7 antibody, mitogen-activated protein kinase 7 L homeolog antibody, MAPK7 antibody, Mapk7 antibody, MPK7 antibody, mapk7.L antibody

Background:

Background: Plays a role in various cellular processes such as proliferation, differentiation and cell survival. The upstream activator of MAPK7 is the MAPK kinase MAP2K5. Upon activation, it translocates to the nucleus and phosphorylates various downstream targets including MEF2C. EGF activates MAPK7 through a Ras-independent and MAP2K5-dependent pathway. May have a role in muscle cell differentiation. May be important for endothelial function and maintenance of blood vessel integrity. MAP2K5 and MAPK7 interact specifically with one another and not with MEK1/ERK1 or MEK2/ERK2 pathways. Phosphorylates SGK1 at Ser-78 and this is required for growth factor-induced cell cycle progression. Involved in the regulation of p53/TP53 by disrupting the PML-MDM2 interaction.

Aliases: Big MAP kinase 1 antibody, BMK 1 antibody, BMK 1 kinase antibody, BMK-1 antibody, BMK1 antibody, BMK1 Kinase antibody, EC 2.7.11.24 antibody, ERK 4 antibody, ERK 5 antibody, ERK-5 antibody, ERK4 antibody, ERK5 antibody, Extracellular signal regulated kinase 5 antibody, Extracellular signal-regulated kinase 5 antibody, MAP kinase 7 antibody, MAPK 7 antibody, MAPK7 antibody, Mitogen activated protein kinase 7 antibody, Mitogen-activated protein kinase 7 antibody, MK07_HUMAN antibody, OTTHUMP00000065906 antibody, OTTHUMP00000065907 antibody, PRKM 7 antibody, PRKM7 antibody, PROTEIN KINASE, MITOGEN-ACTIVATED, 7 antibody

UniProt: Q13164

Pathways: MAPK Signaling, Neurotrophin Signaling Pathway, Activation of Innate immune Response, cAMP Metabolic Process, Toll-Like Receptors Cascades, Negative Regulation of intrinsic apoptotic Signaling