RPUSD4 antibody (AA 41-240)

Catalog No. ABIN7159947

Product Details anti-RPUSD4 Antibody

Target: RPUSD4 (RNA Pseudouridylate Synthase Domain Containing 4 (RPUSD4))

Binding Specificity: AA 41-240

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RPUSD4 antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human Mitochondrial RNA pseudouridine synthase RPUSD4 protein (41-240AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:500-1:2000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for RPUSD4

Target: RPUSD4 (RNA Pseudouridylate Synthase Domain Containing 4 (RPUSD4))

Alternative Name: RPUSD4 (RPUSD4 Products)

Synonyms: 2410001E19Rik antibody, RGD1311268 antibody, RNA pseudouridylate synthase domain containing 4 antibody, RPUSD4 antibody, Rpusd4 antibody

Background:

Background: Catalyzes uridine to pseudouridine isomerization (pseudouridylation) of different mitochondrial RNA substrates. Acts on position 1397 in 16S mitochondrial ribosomal RNA (16S mt-rRNA). This modification is required for the assembly of 16S mt-rRNA into a functional mitochondrial ribosome (PubMed:27974379). Acts on position 39 in mitochondrial tRNA(Phe) (PubMed:28082677). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mt-rRNA, controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664).

Aliases: RNA pseudouridylate synthase domain-containing protein 4 antibody, rpusd4 antibody, RUSD4_HUMAN antibody

UniProt: Q96CM3