CHCHD4 antibody (AA 1-142) (Biotin)

Catalog No. ABIN7159924

Product Details anti-CHCHD4 Antibody (Biotin)

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Binding Specificity: AA 1-142

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CHCHD4 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mitochondrial intermembrane space import and assembly protein 40 protein (1-142AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for CHCHD4

Target: CHCHD4 (Coiled-Coil-Helix-Coiled-Coil-Helix Domain Containing 4 (CHCHD4))

Alternative Name: CHCHD4 (CHCHD4 Products)

Synonyms: 2410012P20Rik antibody, 2810014D17Rik antibody, AI838740 antibody, MIA40 antibody, TIMM40 antibody, mia40 antibody, timm40 antibody, chchd4 antibody, chchd4a antibody, fc10g04 antibody, wu:fc10g04 antibody, zgc:100849 antibody, si:dkey-202e22.1 antibody, chchd4b antibody, CaO19.2977 antibody, coiled-coil-helix-coiled-coil-helix domain containing 4 antibody, coiled-coil-helix-coiled-coil-helix domain containing 4 L homeolog antibody, coiled-coil-helix-coiled-coil-helix domain containing 4a antibody, coiled-coil-helix-coiled-coil-helix domain containing 4 S homeolog antibody, Mia40p antibody, Chchd4 antibody, CHCHD4 antibody, chchd4 antibody, chchd4.L antibody, chchd4a antibody, chchd4.S antibody, LOC100361898 antibody, MIA40 antibody

Background:

Background: Functions as chaperone and catalyzes the formation of disulfide bonds in substrate proteins, such as COX17. Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS. Reduced CHCHD4/MIA40 is then reoxidized by GFER/ERV1 via a disulfide relay system.

Aliases: CHCHD4 antibody, MIA40Mitochondrial intermembrane space import and assembly protein 40 antibody, Coiled-coil-helix-coiled-coil-helix domain-containing protein 4 antibody

UniProt: Q8N4Q1