C20orf72 antibody (AA 81-260) (Biotin)

Catalog No. ABIN7159875

Product Details anti-C20orf72 Antibody (Biotin)

Target: C20orf72 (MGME1) (Mitochondrial Genome Maintenance Exonuclease 1 (MGME1))

Binding Specificity: AA 81-260

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This C20orf72 antibody is conjugated to Biotin

Application: ELISA

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Mitochondrial genome maintenance exonuclease 1 protein (81-260AA)

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for C20orf72

Target: C20orf72 (MGME1) (Mitochondrial Genome Maintenance Exonuclease 1 (MGME1))

Alternative Name: MGME1 (MGME1 Products)

Synonyms: C20orf72 antibody, DDK1 antibody, MTDPS11 antibody, bA504H3.4 antibody, mitochondrial genome maintenance exonuclease 1 antibody, MGME1 antibody

Background:

Background: Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5\'-3\' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair. Specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells.

Aliases: MGME1 antibody, C20orf72 antibody, DDK1Mitochondrial genome maintenance exonuclease 1 antibody, EC 3.1.-.- antibody

UniProt: Q9BQP7