Midkine antibody (AA 21-143)

Catalog No. ABIN7159804

Product Details anti-Midkine Antibody

Target: Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))

Binding Specificity: AA 21-143

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Midkine antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Midkine protein (21-143AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for Midkine

Target: Midkine (MDK) (Midkine (Neurite Growth-Promoting Factor 2) (MDK))

Alternative Name: MDK (MDK Products)

Background:

Background: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development

Aliases: Amphiregulin associated protein antibody, Amphiregulin-associated protein antibody, ARAP antibody, FLJ27379 antibody, Mdk antibody, Midgestation and kidney protein antibody, Midkine antibody, MK 1 antibody, MK antibody, MK_HUMAN antibody, MK1 antibody, NEGF 2 antibody, NEGF2 antibody, Neurite growth promoting factor 2 antibody, Neurite outgrowth promoting protein antibody, Neurite outgrowth-promoting factor 2 antibody, Neurite outgrowth-promoting protein antibody, Retinoic acid inducible factor antibody

UniProt: P21741

Pathways: RTK Signaling, M Phase, Skeletal Muscle Fiber Development